Known reported in the pathogenesis of NOA are No. 5, No. 6, No. 10, and Y chromosome.[7–10] Genes that have been reported on the Y chromosome included AZF, zinc finger protein, Y linked (ZFY), amelogenin, Y-linked (AMELY), transducin Beta-like 1Y (TBL1Y), testis-specific protein Y-linked (TSPY), etc.[10] The AZF region on the Y chromosome is one of the most intensively studied regions in male infertility.[11,12] The deletion of the AZFc region of the Y chromosome is the most frequent molecularly defined cause of spermatogenic failure. Here, ZNF146 is linked to spermatogenic failure.