KLF4 and neoplasm: According to the score statistics of staining degree and the staining area, high KLF4 expression rate in para-tumorous tissues was 58.92% (109 of 185: 16 of strong and 93 of moderate) while high KLF4 expression rate in HCC tissues was 23.78% (44 of 185: 4 of strong and 40 of moderate), which showed KLF4 expression in tumor tissues is lower than the paired para-tumorous tissues (*P <0.05) (Figure 1C).