As showing in Table 1 and Figure 2, there were 5 downregulated proteins (ANPEP; aminopeptidase N, ANXA2; annexin A2, CAV1; caveolin-1, CSPG4; chondroitin sulfate proteoglycan 4, and TGM2; transglutaminase 2) associated with blood vessel/vasculature development in suspended melanoma cells; while 4 downregulated proteins (ANPEP, CAV1, CHD7; Chromodomain-helicase-DNA-binding protein 7, and TGM2) associated with blood vessel/vasculature development in re-attached melanoma cells. This evidence concerns the gene ANPEP and melanoma.