Mevalonate is an essential precursor for production of isoprenoids, which are important for anchoring small GTPases.5 Inactivation of Rab GTPases, which are essential for intracellular vesicle trafficking, appears to be an important process in the development of rhabdomyolysis.9 Statin-induced rhabdomyolysis is dose dependent, especially when employed with agents that are also myotoxic or increase statin concentration. The gene discussed is RAB6A; the disease is rhabdomyolysis.