Animal experiments also have confirmed that estrogen can improve limb motor function, and there exists sex difference in neuropathology and cognitive behavior in APP/PS1/Tau triple‐transgenic mouse model of Alzheimer's disease (Späni et al. 2018; Raghava et al. 2017; Yang et al. 2018). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.