The majority of T‐ALL‐specific OCRs (44,323/46,188; 96%) were mapped to non‐TSS OCRs suggesting that leukemia‐specific OCRs are enriched for putative gene regulatory regions with an at least three‐fold increase in accessible motifs for TFs with a key role in T‐ALL such as REST and MAF:NFE2 (Dataset EV8). Here, REST is linked to acute lymphoblastic leukemia.