TDP acts at key steps of glucose metabolism: In the pentose shunt, TDP is a coenzyme of transketolase; in the tricarboxylic acid (TCA) cycle, TDP is a coenzyme both for pyruvate dehydrogenase complex (PDHC) and ketoglutarate dehydrogenase complex (KGDHC) (Chen & Zhong, 2013; Gibson & Blass, 2007; Gibson et al., 2013, 2016);thus, thiamine deficiency would interfere the metabolism of glucose. The gene discussed is TKT; the disease is Thiamine deficiency.