CASP3 and cancer: The anti-cancer agent cisplatin is known to induce programmed cell death via caspase (-3, -6, -7, and -8)-dependent and -independent mechanisms [42–44], and since caspase-3 is responsible for apoptosis of neurons and astrocytes [45], we wanted to explore if the LAT1-utilizing prodrug could affect decreased cell viability induced by cisplatin in vitro.