NKCC1 is expressed in the basolateral membrane of epithelia in various organs, transporting chloride across the basolateral membrane into the epithelial cells where chloride then can be secreted.3 The severely reduced saliva in our proband closely resembles the deficient saliva secretion from the parotid gland shown in SLC12A2 knockout mice.19 The S aureus parotitis of the proband and her sister was assumingly caused by obstruction of the parotid duct due to reduced secretion. This evidence concerns the gene SLC12A2 and parotitis.