In a recent study, a positive feedback loop has been demonstrated between SOX4 and a scaffold protein Cullin 4B (CUL4B), wherein CUL4B induces the SOX4 expression via PRC2-mediated silencing of miR-204 and in turn SOX4 positively regulates the transcription of CUL4B, leading to enhanced proliferation and invasion of PCa cells. Here, CUL4B is linked to posterior cortical atrophy.