Importantly, androgen deprivation in mice implanted with human LuCaP35 prostate tumor induces the increased expression of N-Cadherin (CDH2), VIM, ZEB1, TWIST1, and SLUG. Notably, a bidirectional negative feedback loop is generated between AR and Zeb1 which is involved in androgen deprivation induced EMT (Sun et al., 2012). Here, ZEB1 is linked to prostate neoplasm.