Evaluation of the transcription factors involved in lineage plasticity in prostate tumors showed SRY-box transcription factor 2 (SOX2) to be highly upregulated in tumors with altered TP53 and RB1 (TP53Alt, RB1Alt) compared to wildtype TP53 and RB1 (TP53WT, RB1WT) tumors. The gene discussed is RB1; the disease is prostate neoplasm.