Furthermore, the role of SOX2 has been reported in repressing adenocarcinoma specific genes by enhancing the expression and activity of lysine-specific demethylase 1A (LSD1/KDM1A) (Li et al., 2019), highlighting the potential of SOX2 as a lineage reprogramming factor in neuroendocrine prostate tumors. This evidence concerns the gene KDM1A and prostate neuroendocrine neoplasm.