The tumor microenvironment includes blood vessels, stromal cells namely, cancer-associated fibroblasts (CAFs), endothelial cells, neuroendocrine cells and infiltrating immune cells, growth factors and chemokines secreted by either tumor cells or stromal cells and many extracellular matrix proteins such as laminin, fibronectin, and collagen (Yates, 2011). Here, FN1 is linked to neoplasm.