Therefore, increased Col-IV protein expression was found in kidneys in various animal models of hypertension such as spontaneously hypertensive rats (60), angiotensin II-induced hypertension (61) or 2 kidneys, 1 clip model of hypertension (62), and also in patients with preeclampsia or other hypertensive syndromes in pregnancy (63). This evidence concerns the gene AGT and preeclampsia.