PDCD10 and cerebral cavernous malformation: For instance, PDCD10 mutations are responsible for CCM (Guclu et al., 2005; Chen et al., 2009), and loss of PDCD10 dissociated ZO-1 and actin via phosphorylation of cortactin, which caused instability of tight junction complex and consequently impairment of brain barrier integrity (Stamatovic et al., 2015).