Imatinib inhibits tumor growth of ES cells in vivo and in vitro by suppressing activation of SCF-mediated c-kit (Merchant et al., 2002); however, a clinical trial evaluating imatinib failed to demonstrate clinical benefits in patients with ES (ClinicalTrials.gov Identifier: NCT00154388) (Chugh et al., 2009). The gene discussed is KIT; the disease is Ewing sarcoma.