IGF-1R and tyrosine kinase-like orphan receptor 1 (ROR1) are highly expressed in ES cells, and the application of adoptive T-cell therapy using IGF-1R-CAR-T and ROR1-CAT-T cells derived from sarcoma patients significantly increases ES cell death and reduces tumor growth of sarcoma xenografts (Huang et al., 2015). Here, ROR1 is linked to neoplasm.