Treatment with RITA (reactivating p53 and inducing tumor apoptosis), a furanic compound, significantly suppressed cell growth and metastatic potential in ES cells via RITA-induced downregulation of IGF-1R as a transcriptional target of p53, as well as the degradation of IGF-1R by RITA-mediated upregulation of murine double minute-2 (MDM2) (Di Conza et al., 2012). This evidence concerns the gene TP53 and neoplasm.