IGF1R and neoplasm: In one study, IGF-1R was reportedly upregulated in all the tumor samples, including those from ES and synovial sarcoma patients, and inhibition of the IGF-1R signaling pathway resulted in a loss of the invasive ability of ES cells (Figure 1; Scotlandi et al., 1996; Xie et al., 1999; Asmane et al., 2012).