CASP8 and cancer: IFN-β demonstrates potential anti-tumorigenic effects on tumor cells, as well as immune-infiltrating cells (Musella et al., 2017), reducing tumor cell growth in various type of cancers through by suppressing PI3K/AKT activation, reducing anti-apoptotic proteins, including FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) and caspase-8, and activating the TNF-related-apoptosis-inducing ligand (TRAIL)-dependent pathway (Chawla-Sarkar et al., 2001; Dedoni et al., 2010; Apelbaum et al., 2013).