Metformin, in combination with 5-fluorouracil and oxaliplatin (FuOX), induced cell death in chemoresistant colon cancer cells by suppressing cancer stem cells (CSC) characteristics, STAT3, and NF-κB activation (Nangia-Makker et al., 2014) and suppressing STAT3 and NF-κB activation (Lin et al., 2013; Feng et al., 2014; Yue et al., 2015; Esparza-Lopez et al., 2019). This evidence concerns the gene STAT3 and malignant colon neoplasm.