HER2-specific chimeric antigen receptor (HER2-CAR) T-cells from healthy donors markedly reduced the proliferation of HER2-positive medulloblastoma cells, and HER2-CAR-T-cells from HER2-positive patients killed primary autologous HER2-positive medulloblastoma cells in vivo and in vitro by the inducing interferon (IFN)-γ production (Ahmed et al., 2007; Thanindratarn et al., 2020). The gene discussed is ERBB2; the disease is medulloblastoma.