Strikingly, 2 days of BL-8040 monotherapy induced apoptosis and 40.2-fold mobilization of immature AML progenitors (CD45+/low CD34+ CD117+ HLA-DR+), resulting in a median decrease of 57.7% in the number of bone marrow leukemia progenitor cells out of total CD45+ CD34+ normal progenitor cells. Here, PTPRC is linked to leukemia.