JAM-C was related to overactivation of Src family kinase (SFK) in LSC (De Grandis et al., 2017), pathway previously described as constitutively active in many cases in AML patients and involved in signal transduction from a variety of receptors including FLT3 (Robinson et al., 2005; Dos Santos et al., 2008). The gene discussed is JAM3; the disease is acute myeloid leukemia.