Conversely, interference with the binding of EVI1 to the GPR56 promoter through GPR56-specific pyrrole-imidazole polyamides treatment of immunodeficient Balb/c-RJ mice subcutaneously transplanted with the EVI1high UCSD/AML1 cell lines inhibited tumor growth and improved survival (Saha et al., 2018). Here, RUNX1 is linked to neoplasm.