In addition, heparin reduced acute promyelocytic leukemia cell line NB4 adhesion to the immortalized human microvascular endothelial cell line-1 (HMEC-1), and the expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) on HMEC-1 cells (Vignoli et al., 2018). This evidence concerns the gene ICAM1 and acute promyelocytic leukemia.