In fact, when high levels of CXCR4 are expressed at the membrane of AML cells, blocking the receptor function with AMD3100 or the peptide TN140 was sufficient to reduce the number of LSC in NOD/Shi-SCID/IL2Rγ–/– (NOG) mice (Zhang et al., 2012b). This evidence concerns the gene IL2RG and acute myeloid leukemia.