Besides the canonic effect, TR has been applied in several inflammatory disease including bronchial asthma, atypical dermatitis, allergic conjunctivitis, and hypertrophic scars (Darakhshan and Pour, 2015) by directly binding to the NACHT domain of NLRP3 to suppress the of NLRP3 inflammasome (Huang et al., 2018). The gene discussed is NLRP3; the disease is atopic conjunctivitis.