EZH2 and brain neoplasm: Enhancer of zeste homolog 2 (EZH2), which is part of a Polycomb repressor complex that methylates lysine 27 of histone H3 (H3K27), leading to transcription inhibition, is often mutated or highly expressed in pediatric brain tumors (Huether et al., 2014; Li et al., 2015; Kim and Roberts, 2016; Erkek et al., 2019; Zhang et al., 2020).