TGFB1 and neoplasm: Tumor cells consistently release many immuno-suppressive and pro-inflammatory factors such as vascular endothelial growth factor (VEGF), TGF-β, IL-10, PGE2, eNOS, which induce tumor-infiltrating immune cells to be tolerance (Zhang et al., 2004; Zou, 2005; Kim et al., 2006; Tang et al., 2006; Rabinovich et al., 2007; Xia et al., 2008).