RUNX1 and acute myeloid leukemia: Common genetic abnormalities in AML with high frequency and well-established favorable prognostic significance include t(8;21)(q22;q22) (RUNX1-RUNX1T1), inv(16) (p13;q22) (CBFB-MYH11), and t(15;17)(q24;q21) (PML-RARA).