Most common for pediatric AML are translocations t(9;11)(p21.3;q23.3) (MLL-MLLT3), t(10;11)(p12;q23.3) (MLL-MLLT10), t(11;19)(q23.3;p13.1) (MLL-ELL), and t(6;11)(q27;q23.3) (MLL-AFDN) (7–9). The gene discussed is KMT2A; the disease is acute myeloid leukemia.