MNX-AS1 was reported to act as a functional oncogene that induces aggressiveness by numerous manners such as activating MAPK pathway in cervical cancer (20) and acting as a sponge to miR-218-5p/COMMD8 axis in hepatocellular carcinoma (21) and to miR-34a/SIRT1 axis in esophageal squamous cell carcinoma (22). Here, SIRT1 is linked to esophageal squamous cell carcinoma.