In conclusion, differently from other drugs that preferentially kill mutp53 carrying cancer cells (41), we found that the cytotoxic effect of STAT3 inhibition goes behind its-capacity to down-regulate mutp53, as AG490 efficiently impaired cell survival also of wtp53 carrying glioblastoma cells, in correlation with p53 activation and the mevalonate pathway inhibition. This evidence concerns the gene TP53 and cancer.