In conclusion, differently from other drugs that preferentially kill mutp53 carrying cancer cells (41), we found that the cytotoxic effect of STAT3 inhibition goes behind its-capacity to down-regulate mutp53, as AG490 efficiently impaired cell survival also of wtp53 carrying glioblastoma cells, in correlation with p53 activation and the mevalonate pathway inhibition. The gene discussed is TP53; the disease is glioblastoma.