Among the several isoforms of TGF-β, TGF-β1 is a predominant isoform in humans and plays pivotal roles in modulation of cellular growth, maturation, and differentiation; extracellular matrix formation; homeostasis; endothelial cell plasticity; immunoregulation; apoptosis; angiogenesis; and cancer progression. Here, TGFB1 is linked to cancer.