FLT3 and acute myeloid leukemia: There are many past and present clinical trials examining the activity of tyrosine kinase inhibitors (TKIs) against FLT3 mutant AML, including sunitinib, midostaurin, lestaurtinib, sorafenib, ponatinib, crenolanib, gilteritinib, and quizartinib [8, 12–18].