Genome-wide plasma lncRNA profiles were screened to identify promising GC lncRNA biomarkers, with the result that plasma levels of FAM49B-AS, GUSBP11, and CTDHUT in GC patients were found to be significantly higher than in healthy controls after validation with data from 446 subjects (AUC of 0.818, 95% CI, 0.772-0.864). Here, CYRIB is linked to gastric cancer.