Moreover, in GC cells in which LMX1A is knocked out, over-expressing or silencing KCNQ1OT1 is completely ineffective, consistent with the notion that KCNQ1OT1 participates in GC progression by regulating the expression of miR-9-LMX1A 50. The gene discussed is KCNQ1OT1; the disease is gastric cancer.