Moreover, miR-141 and miR-200a are known to be negative regulators of the ZEB1 gene and EMT pathway; MAGI2-AS3, mainly located in the cytoplasm, promotes tumor metastasis by binding miR-141/200a to maintain downstream ZEB1 over-expression, which is a well-accepted core factor regulating the EMT process 128,129. This evidence concerns the gene ZEB1 and neoplasm.