KDM4D and liver cancer: As shown in Figure 2F and 2G, knockdown of JMJD2D significantly decreased Ki67-positive cell number, whereas it increased TUNEL-positive cell number in the tissue sections from JMJD2D-knockdown tumors, indicating that downregulation of JMJD2D inhibits liver cancer cell proliferation but promotes liver cancer cell apoptosis in vivo.