TP53 and liver cancer: We observed that knockout of p53 significantly impaired the effects of JMJD2D knockdown on liver cancer cell proliferation and apoptosis, but knockdown JMJD2D could still partially inhibit cell proliferation of p53-KO cells, whereas overexpression of JMJD2D could promote the proliferation of p53-KO cells (Figure S12), suggesting that apart from p53 signal pathway, JMJD2D regulates liver cancer cell proliferation through other signal pathways.