Intriguingly, their study concludes that JMJD2D cooperates with p53 to induce the expression of cell cycle inhibitor p21 as demonstrated by the observations that combination of p53 and JMJD2D synergistically activate the p21 promoter reporter in HEK293T cells and overexpression of JMJD2D promotes p21 protein expression in U2OS osteosarcoma cells 33. This evidence concerns the gene KDM4D and osteosarcoma.