On the basis of miR‐378a enhancing the sensitivity of liver cancer to sorafenib by targeting VEGFR, PDGFRβ and c‐Raf31, we further confirmed that the expression of miR-378a-3p was decreased in sorafenib-resistant HCC cells and identified IGF1R as the target gene of miR-378a-3p. Here, IGF1R is linked to hepatocellular carcinoma.