ADAR and chronic myelogenous leukemia, BCR-ABL1 positive: In human chronic myeloid leukemia (CML), ADAR1 activation enhances self-renewal capacity of leukemia stem cells (LSCs) by editing let-7 pri-microRNA (pri-miRNA), resulting in impaired let-7 biogenesis and increased LIN28B pluripotency gene expression 109, 110.