Similarly, the inactivation of STAT3 in PTEN-deficient tumors activates immunosurveillance in prostate cancer by reducing the expression of cytokines including CXCL2, GM-CSF, M-CSF, C5a, IL10, and IL13, thereby displaying the immunostimulatory features of the senescence-associated secretory phenotype of tumor cells 75. Here, STAT3 is linked to prostate cancer.