Furthermore, in colon cancer, the internalized CD44 and acetyltransferase p300 induce STAT3 acetylation at Lysine (Lys) 685, which in turn promotes the expression of cell cycle regulators cyclin D1 70, MYC, and Twist1 in colon cancer cells 71. The gene discussed is CCND1; the disease is malignant colon neoplasm.