We performed Kaplan-Meier analysis of a TCGA cohort of 364 CRC patients (Table S2) and found that high expression of C3, C5, and C5AR1 but not of C5AR2 significantly predicted poor overall survival (Figure 1A to D), indicating the potential role of complement activation during CRC progression. The gene discussed is C5AR1; the disease is colorectal carcinoma.