Accumulating evidence has suggested that chronic colitis promotes tumorigenesis mainly by altering the production of a variety of cytokines/chemokines, such as TNF-α, IL-1/6/10, TGF-β, CCL2/4, and CXCL1/2/5 3, 4, 31, 32. Here, CXCL1 is linked to Chronic colitis.