The local levels of proinflammatory chemokines such as CCL2, CCL3, CCL4, and CCL5 and proangiogenic chemokines such as CXCL1, CXCL5, and CXCL8 are elevated in human colon tumor tissues compared to those in paired normal tissues 47, 48. The gene discussed is CCL2; the disease is colonic neoplasm.