Considering the fact that BMP down-regulation is usually observed in the progress of osteoporosis, accumulating evidences have revealed that simvastatin (Sim) can increase the expression of BMP-2 in osteoblasts and promotes the formation of new bone through the BMP-Smad signaling pathway 23, 24, which may be applied as a novel drug for the treatment of osteoporosis to break traditional methods of inhibiting osteoclast activity 4, 25. Here, BMP2 is linked to osteoporosis.