(1) Protein synthesis blocker CHX caused a gradual decrease in CD147 protein abundance in control RCC cells; however, the CHX-induced reduction of CD147 protein abundance was attenuated by HSPA12A knockdown, (2) Treatment with the proteasome inhibitor MG132 abolished the HSPA12A overexpression-induced decrease of CD147 protein, (3) In the ubiquitin immuno-precipitates from HSPA12A-overexpressing RCC cells, CD147 was present at a higher level, and the opposite pattern was observed in response to HSPA12A knockdown, and (4) HSPA12A showed an interaction with E3 ubiquitin ligase HRD1. The gene discussed is SYVN1; the disease is renal cell carcinoma.