Notably, immunoprecipitation-immunoblotting analysis revealed the presence of HRD1 protein in the Flag-tagged HSPA12A immuno-precipitates from Ad-HSPA12A Caki-1 or 786O cells, showing the interaction of HSPA12A with HRD1 in RCC cells (Figure 9C). The gene discussed is SYVN1; the disease is renal cell carcinoma.