ZFP91 and hepatocellular carcinoma: However, when ZFP91 was coexpressed with wild-type hnRNP A1 or hnRNP A1 K8R in HCC cells, ZFP91 overexpression did not antagonize the increased Warburg effect induced by hnRNP A1 K8R mutant overexpression because ZFP91 did not ubiquitinate and degrade hnRNP A1 K8R mutant protein (Figure 7G and 7H).