Interestingly, ZFP91 mRNA and protein levels are downregulated in all six primary HCC tissue samples compared with matched adjacent nontumoral hepatic tissue samples (Figure 1A and 1B), which is inconsistent with previous studies in which ZFP91 expression is upregulated in AML, prostate and colon cancer tissues 30-32. The gene discussed is ZFP91; the disease is acute myeloid leukemia.