In addition to the c-myc-induced transcription, we provide another fashion of the upregulation of hnRNP A1 protein levels in cancer cells in which the ubiquitin-mediated degradation of hnRNP A1 was impaired because the E3 ubiquitin ligase ZFP91 of hnRNP A1 was downregulated or absent in HCC cells. The gene discussed is MYC; the disease is cancer.