In the case of the midnightblue module, some of the highly connected genes including GSN (Polgar et al., 2012), CCR6 (Polgar et al., 2012), SOCS2 (Rupp et al., 2015), THBS1 (Wang X.G. et al., 2016), IL1R1, and IL1RAP (Bonnefont et al., 2011) were involved in mastitis defense or immune response. The gene discussed is IL1R1; the disease is mastitis.