It was interesting to note that the four samples share a high annotation frequency (>10) for the Wolcott–Rallison syndrome, a rare autosomal recessive disease, characterized by neonatal or early-onset non-autoimmune insulin-requiring diabetes associated with skeletal dysplasia and growth retardation (Julier and Nicolino, 2010). The gene discussed is INS; the disease is autosomal recessive disease.