The regional chr9p21 GWAS signal has also been associated with T2D, but this association is not mediated by ANRIL, as the association signal for T2D is separated from that for atherosclerosis by a recombination hot spot that renders the two disease association signals in linkage equilibrium (Dauriz and Meigs, 2014). The gene discussed is CDKN2B-AS1; the disease is type 2 diabetes mellitus.