CRP and type 2 diabetes mellitus: This chromosome 8 locus is highly pleiotropic, and rs4841132 and nearby SNPs have been consistently associated with increased T2D risk as well as T2D-related metabolic phenotypes including glycemia in pregnancy, obesity, HDL:LDL ratio, total cholesterol, triglycerides, C-reactive protein levels, coronary artery disease, subclinical atherosclerosis, and fatty liver disease (Lettre et al., 2011; Speliotes et al., 2011; Inouye et al., 2012; Manning et al., 2012; Hayes et al., 2013; Willer et al., 2013; Ligthart et al., 2015; Raffield et al., 2017).