Indeed, evidence for common genetic variation in PPP1R3B itself has been inconsistent for T2D risk in humans (Dunn et al., 2006; Liu et al., 2016), although rare variants in PPP1R3B are associated with human diabetes phenotypes (Abdulkarim et al., 2015; Niazi et al., 2019). This evidence concerns the gene PPP1R3B and diabetes mellitus.