PPP1R3B and type 2 diabetes mellitus: Taken together, the functional data we present support the contention that the lncRNA LOC157273 is a causal transcript at the chr8p23.1 GWAS locus, controlling T2D risk and metabolic physiology by hepatic regulation of PPP1R3B (and most likely other) transcription, thereby influencing variation in glycemia, other metabolic phenotypes, and T2D risk observed in genetic association studies.