For example, the anti-TNF antibody Adalimumab reduces inflammation in a number of autoimmune diseases including Crohn's disease, ulcerative colitis, plaque psoriasis, rheumatoid arthritis and ankylosing spondylitis (2, 3); Dupilumab is an anti-IL-4Rα monoclonal antibody used to treat allergic diseases (4); and Mepolizumab blocks IL-5 and ameliorates the symptoms of patients suffering from severe eosinophilic asthma (5). This evidence concerns the gene IL4R and allergic disease.