In fact, Stx2 is more frequently associated, compared to Stx1, to HUS and haemorrhagic colitis and even more striking is the association between HUS and the subtypes Stx2a, Stx2c and Stx2d (Fuller et al., 2011; Melton-Celsa, 2014; Krüger and Lucchesi, 2015). Here, STX2 is linked to hemolytic-uremic syndrome.