We applied multiple levels of analysis (hormonal, molecular and genetic) to test the association of conversion to psychosis with potential biomarkers from the biological stress pathway (NR3C1 expression level and cortisol levels at different times of the day), while adjusting for age, sex, cannabis use, and antipsychotic intake, in a longitudinal cohort of 133 subjects at-risk for psychosis. The gene discussed is NR3C1; the disease is psychotic disorder.