NR3C1 and psychotic disorder: In females, we identified a SNP (rs6849528) strongly associated with NR3C1 expression, and the odds of conversion to psychosis appeared significantly increased in the group with the minor allele A. Because the probability of distribution of alleles is independent of environmental factors, this SNP’s association with psychosis confirmed the involvement of NR3C1 expression in the risk of psychosis, independently of any non-genetic confounder (Figure 4).