Using a French longitudinal prospective cohort of individuals at-risk for psychosis, presenting attenuated or prodromal symptoms [ICAAR, previously described (23)], with data on cortisol levels, NR3C1 expression levels, and whole-genome genotyping, we thus tested the following hypotheses in a Mendelian randomization framework (Figure 2). The gene discussed is NR3C1; the disease is psychotic disorder.