The results had hinted that obvious species differentiation of normal and DSS+SSP groups did not stimulate the proliferation of CD11c+CD103+E-cadherin+ cells, or SSP administrations led to some probiotics development to inhibit CD11c+CD103+E-cadherin+ cells hyperplasia and protected colonic mocusa from colitis mice. The gene discussed is ITGAE; the disease is colitis.