Our previous studies have shown that SSP attenuates the symptoms of trinitrobenzene-sulfonic-acid induced colitis by restraining nuclear factor-κB activation via inhibiting the NEMO/NLK signaling pathway (Wang et al., 2019), indicating that SSP had certain effect on colitis, but whether it affected the development of ulcerative colitis by another way has not been known. The gene discussed is IKBKG; the disease is colitis.