However, overexpression of Plscr4, in this case, leads to attenuation of cardiac hypertrophy, which appears to occur through altering the miR-214-Mitofusin 2 (Mfn2) pathway and maintaining mitochondrial homeostasis in mice subjected to pressure overload via Transverse Aortic Constriction (TAC) surgery. This evidence concerns the gene MFN2 and cardiac hypertrophy.