TLR4 and cardiac hypertrophy: Additionally, as described previously, MIAT expression is upregulated in cardiomyocytes under AngII treatment, participating as an inducer of cardiac hypertrophy by activation of the PI3K/Akt/mTOR pathway via TLR4 upregulation by sponging miR-93 in cardiomyocytes (Li et al., 2018b).