In addition to the difference analysis of each KNMS in different formulas, KEGG enrichment analysis of all KNMSs in each formula were also implemented and revealed that 3 formulas exert the therapeutic effect of RA through common pathway, such as MAPK signaling pathway, cAMP signal pathway etc. or specific pathway, such as VEGF signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway etc. Among them, MAPK signaling pathway plays an important role in the pathological process of RA (Schett and Zwerina, 2008). The gene discussed is AKT1; the disease is rheumatoid arthritis.