AKT3 and disorder of sexual differentiation: Results show that genes in the KNMSs of DSD mainly distributed in the downstream of the comprehensive inflammatory pathway, such as MAPK14, MAPK8, and JUND; Genes in the KNMSs of GFD mainly distributed in the downstream of the comprehensive inflammatory pathway, such as AKT3, RAF1, and TAOK3; while genes in the KNMSs of HGWD distributed both in the upstream and downstream of the comprehensive inflammatory pathway, such as CSF1R, ADCYAP1R1, CHRM1, NFKB1, MAPT, and JUN.