Results show that genes in the KNMSs of DSD mainly distributed in the downstream of the comprehensive inflammatory pathway, such as MAPK14, MAPK8, and JUND; Genes in the KNMSs of GFD mainly distributed in the downstream of the comprehensive inflammatory pathway, such as AKT3, RAF1, and TAOK3; while genes in the KNMSs of HGWD distributed both in the upstream and downstream of the comprehensive inflammatory pathway, such as CSF1R, ADCYAP1R1, CHRM1, NFKB1, MAPT, and JUN. The gene discussed is MAPK8; the disease is disorder of sexual differentiation.