In order to further explore the potential mechanism of the three formulas in treating RA, besides the difference analysis of each KNMS in different formulas, KEGG enrichment analysis of all KNMSs in each formula were also implemented and found that 3 formulas play the therapeutic effect on RA through the following five common pathways: Rap1 signaling pathway, cAMP signaling pathway, MAPK signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, Calcium signaling pathway and Neuroactive ligand-receptor interaction. Here, EGFR is linked to rheumatoid arthritis.