The arthritis-related signaling pathways corresponding to DSD1 and DSD2 were partially complementary, for example, genes in DSD1 were mainly enriched in JAK-STAT signaling pathway and AMPK signaling pathway, genes in DSD2 mainly enriched in NF-kappa B signaling pathway, p53 signaling pathway and Wnt signaling pathway. This evidence concerns the gene TP53 and arthritic joint disease.