Sometimes amyloidogenesis occurs when a protein concentration is persistently elevated, like for the acute phase reactant serum amyloid A (SAA) in systemic amyloidosis associated to chronic inflammation (AA amyloidosis) or wild-type β2-microglobulin in systemic amyloidosis associated to dialysis (Westermark et al., 2015; Kaneko and Yamagata, 2018). This evidence concerns the gene HLA-G and primary systemic amyloidosis.