In this study, consistent with previous findings (Kim et al., 2009; Kim and Feldman, 2012), we found that expression levels of p-Tau at Ser 396/404 were remarkably increased both in the hippocampus and cortex, while Zonisamide treatment attenuated Tau phosphorylation in T2DM mice. The gene discussed is MAPT; the disease is type 2 diabetes mellitus.