It has been reported that the protein levels of Hrd1 in the cortex are decreased both in diabetic rats and in AD brain compared to the control group rat and non-AD subjects, and the brains of these diabetic rats and AD patients experienced ER stress (Kaneko et al., 2010; Shruthi et al., 2019). The gene discussed is SYVN1; the disease is Endoplasmic Reticulum Stress.