The level of XBP-1s, GRP78, ATF4, and ATF6, as well as the phosphorylation level of PERK were significantly increased in vehicle-treated T2DM mice, while the levels of the above proteins were significantly reduced in Zonisamide-treated T2DM mice (Figures 6B,D). The gene discussed is EIF2AK3; the disease is type 2 diabetes mellitus.