Consistent with the previous study (Arnold et al., 2014; Rai et al., 2014; Carvalho et al., 2015; Zhao et al., 2018), we observed the decreased expression of p-CREB, PKA-cα, synaptophysin, and PSD95 in type 2 diabetes mice. The gene discussed is CREB1; the disease is type 2 diabetes mellitus.