Noticeably, hrd1 levels were evidently reduced in the cortex of T2DM mice but did not change significantly just with a trend in decrease in the hippocampus, while Hrd1 was upregulated both in the cortex and hippocampus in Zonisamide-treated mice (Figures 6B,D). The gene discussed is SYVN1; the disease is type 2 diabetes mellitus.