The Reactome pathway analysis revealed that PTEN homolog plays a crucial role in the SARS-CoV infection through activation of dendritic cells, production of hyperactive B-cells and uncontrolled T-cells, and secretion of proinflammatory cytokines including interferons (IFNs), TNF-α, IL-10, IL-4, and granulocyte monocyte-colony stimulating factor (GM-CSF) [73]. The gene discussed is TNF; the disease is severe acute respiratory syndrome.