ACE2 and malaria: In a study in 2005 that was performed on the prophylactic and therapeutic supremacies of chloroquine, as an anti-malaria agent, on primate cells infected with SARS-CoV, it was defined that chloroquine increases the endosomal pH and intervene with glycosylation of angiotensin-converting enzyme 2 (ACE2) as the receptor of SARS-CoV on the alveolar cell surface [27].