STAT3 as an upstream regulator regulates 15 downstream target genes of the dataset and STAT3 could be involved in disorders related to inflammatory disorders such as connective tissues,57 vascular disorders such as atherosclerosis, angiogenesis,58 neurological disorders such as Alzheimer’s disorders59 and others based on the downstream target of the DRGs (Table 5, Figure 5). This evidence concerns the gene STAT3 and atherosclerosis.