The complex signal transduction mechanism of IL-6/STAT3 may explicate the widespread effects of the IL6 as a cytokine.19 Monitoring of IL6 in T2DM is of clinical significance as it is involved in many related complications such as atherosclerosis (Figure 8), hypertension (Figure 8), renal damage (Figure 4), metabolic, inflammatory disorders, and organs and tissues damage (Table 5). This evidence concerns the gene STAT3 and type 2 diabetes mellitus.