TNF and metabolic disease: TNF uses different signaling pathways such as NFKBIA, and P38MAPK to exert its effect on lipid transport.24 Such data are supported with the related functions observed in the present study such as fat acid metabolism, and lipolysis (Figure S2), and are interconnected to hypertriglyceridemia as a top disease related to metabolic disorder and considered as the leading platform and risk factor for multiple disorders such as cardiovascular disorders, and progressive neurological disorders (Table 5).