Monitoring the coupled expression of dysregulated proteins such as IL6, INS, LEP, IAPP (Islet Amyloid Polypeptide), AGT, TNF, CCL2, GHRL, KNG1 (Kininogen 1), GCG, RETN, and C3 (Complement C3) could be used as a predictive biomarker of T2DM comorbidities. This evidence concerns the gene IAPP and type 2 diabetes mellitus.