For example, TNF as one of the upstream regulators that are involved in rheumatoid arthritis, and the clinical utility of Adalimumab as antibody and binder to TNF target, could be used for the treatment of active rheumatoid arthritis, which is predicted to inhibit TNF as a target.56 Another question, which disease states could develop based on the activation of the acute phase response signalling signaling pathway in T2DM, the answer, for example, could be involved in the damage of the kidney, immunologic, and neurological disorders (Figures 4, 9A and C). Here, TNF is linked to nervous system disorder.