In conclusion, we have identified FOSL1 as a novel, early, central target in inflammation-induced angiogenesis in primary lung EC and HPMECs, linking sepsis with expression of multiple genes involved with aberrant angiogenesis in the developing lung, including ADAM8, LRG1, RNF213, HPX, CXCR2, PROK2, and SP100, which may contribute to development of BPD. Here, PROK2 is linked to Sepsis.