The combined CT/TT genotype of the 1196C/T SNP and the GC genotype of the 11350G/C polymorphism in the 3′-untranslated region of the TLR4 gene may alter its expression, influence the expression of inflammatory cytokines and chemokines, and increased the risk of nasopharyngeal carcinoma (NPC)49,50. This evidence concerns the gene TLR4 and nasopharyngeal carcinoma.