ANGPTL8 and type 2 diabetes mellitus: In their study, Shankar et al. investigated obese patients with a BMI over 35 kg/m2 and type 2 diabetes mellitus undergoing RYGB surgery and could show that just 2 weeks after surgery, betatrophin levels had dropped significantly, accompanied by improved levels of parameters of glucose metabolism such as plasma glucose, insulin and C-peptide12.