As presented in Table 1, pregnant women with a history of RYGB operation show significantly lower basal (RYGB: 13.66 ± 5.88 vs. obesity: 19.03 ± 4.15 vs. controls: 15.68 ± 6.48; p = 0.016) and dynamic betatrophin levels during the OGTT (see Table 1 and Fig. 1). Here, ANGPTL8 is linked to obesity due to melanocortin 4 receptor deficiency.