We next set out to determine whether SNPs within TSPAN5 might be associated with the length of abstinence until the first drink of alcohol during 3 months of acamprosate treatment for AUD patients enrolled in the Mayo Clinic Center for the Individualized Treatment of Alcoholism clinical trial (Fig. 5a and Supplementary Table 5) [17, 30]. This evidence concerns the gene TSPAN5 and alcohol drinking.