ALB and diabetes mellitus: Additionally, the presence of albuminuria, as assessed by the albumin-to-creatinine ratio of 24-h urine albumin excretion at 8 weeks post-diabetes, was not observed in C5Cre diabetic mice (Fig. 2C), which is consistent with studies showing that mice bred on a C57/Bl6 background are refractory to diabetes-induced kidney disease26.