The diverse tumorigenic effects of IRF4 have been associated with context-dependent functions of IRF4, whereby its interaction with the ETS-family member SPI-B is critical for the survival of ABC-DLBCL, while a positive transcriptional auto-regulatory loop between IRF4 and MYC fuels myeloma cell survival8,18. Here, MYC is linked to diffuse large B-cell lymphoma.