In line with the results obtained in stimulated Ramos cells, the constitutive phosphorylation of IRF4 in U2932 cells was prominently decreased upon silencing of ROCK2 but not ROCK1 (Fig. 4b), suggesting that ROCK2 is also the major ROCK family member responsible for the phosphorylation of IRF4 in ABC-DLBCL. The gene discussed is IRF4; the disease is diffuse large B-cell lymphoma.