The most highly enriched upstream regulator of the ROCK2-controlled geneset was RELA (Fig. 4f), a canonical member of the NF-κB family of transcription factors whose expression is required for the survival of several lymphomas, including ABC-DLBCL, and whose activity was previously shown to be regulated by the ROCKs1,2,21. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.