CD274 and non-small cell lung carcinoma: Little is known about the efficacy of first-line immunotherapy-containing regimens for NSCLC in patients with a poor performance status since this population was excluded from all the seminal phase III clinical trials.1–4 13 14 Although the PePS2 study specifically evaluated the safety and tolerability of pembrolizumab in 60 patients with an ECOG PS of 2, only a small subset of 10 patients received pembrolizumab in the first-line setting with a PD-L1 TPS of ≥50%.15 Here, were report outcomes among 234 patients treated with first-line commercial pembrolizumab.