However, the CheckMate 153 and 171 trials of nivolumab in previously treated NSCLC showed that treatment was mostly safe in the ECOG PS 2 subgroup, with no apparent increase in the risk of immune-related or other toxicities compared with patients with a better ECOG PS.6 7 Nonetheless, our analysis represents the largest retrospective cohort of patients with advanced NSCLC and a PD-L1 TPS ≥50% with an impaired performance status treated with first-line pembrolizumab to date. The gene discussed is CD274; the disease is non-small cell lung carcinoma.