Of the 1426 previously treated patients who subsequently received nivolumab monotherapy in the CheckMate 153 NSCLC trial, the median overall survival (mOS) for the 128 (9%) patients with an ECOG PS of 2 was 4.0 months, compared with 9.1 months for the overall population of patients with an ECOG PS 0-2.6 PD-L1 levels were not available in the majority of patients on this study, and only 12 patients were known to have a PD-L1 Tumor Proportion Score (TPS) of ≥50%. This evidence concerns the gene CD274 and neoplasm.